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Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states

We applied single-molecule photobleaching to investigate the stoichiometry of human Orai1 and Orai3 channels tagged with eGFP and expressed in mammalian cells. Orai1 was detected predominantly as dimers under resting conditions and as tetramers when coexpressed with C-STIM1 to activate Ca(2+) influx...

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Bibliographische Detailangaben
Hauptverfasser: Demuro, Angelo, Penna, Aubin, Safrina, Olga, Yeromin, Andriy V., Amcheslavsky, Anna, Cahalan, Michael D., Parker, Ian
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203769/
https://ncbi.nlm.nih.gov/pubmed/21987805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114814108
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