Hypoxia-induced transcriptional repression of the melanoma-associated oncogene MITF

Microphthalmia-associated transcription factor (MITF) regulates normal melanocyte development and is also a lineage-selective oncogene implicated in melanoma and clear-cell sarcoma (i.e., melanoma of soft parts). We have observed that MITF expression is potently reduced under hypoxic conditions in p...

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Main Authors: Feige, Erez, Yokoyama, Satoru, Levy, Carmit, Khaled, Mehdi, Igras, Vivien, Lin, Richard J., Lee, Stephen, Widlund, Hans R., Granter, Scott R., Kung, Andrew L., Fisher, David E.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203758/
https://ncbi.nlm.nih.gov/pubmed/21949374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106351108
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