Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells

Biallelic inactivation of cancer susceptibility gene BRCA1 leads to breast and ovarian carcinogenesis. Paradoxically, BRCA1 deficiency in mice results in early embryonic lethality, and similarly, lack of BRCA1 in human cells is thought to result in cellular lethality in view of BRCA1's essentia...

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Main Authors: Konishi, Hiroyuki, Mohseni, Morassa, Tamaki, Akina, Garay, Joseph P., Croessmann, Sarah, Karnan, Sivasundaram, Ota, Akinobu, Wong, Hong Yuen, Konishi, Yuko, Karakas, Bedri, Tahir, Khola, Abukhdeir, Abde M., Gustin, John P., Cidado, Justin, Wang, Grace M., Cosgrove, David, Cochran, Rory, Jelovac, Danijela, Higgins, Michaela J., Arena, Sabrina, Hawkins, Lauren, Lauring, Josh, Gross, Amy L., Heaphy, Christopher M., Hosokawa, Yositaka, Gabrielson, Edward, Meeker, Alan K., Visvanathan, Kala, Argani, Pedram, Bachman, Kurtis E., Park, Ben Ho
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203756/
https://ncbi.nlm.nih.gov/pubmed/21987798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110969108
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