Cisplatin ototoxicity involves cytokines and STAT6 signaling network

We herein investigated the role of the STAT signaling cascade in the production of pro-inflammatory cytokines and cisplatin ototoxicity. A significant hearing impairment caused by cisplatin injection was observed in Balb/c (wild type, WT) and STAT4(−/−), but not in STAT6(−/−) mice. Moreover, the exp...

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Main Authors: Kim, Hyung-Jin, Oh, Gi-Su, Lee, Jeong-Han, Lyu, Ah-Ra, Ji, Hye-Min, Lee, Sang-Heon, Song, Jeho, Park, Sung-Joo, You, Yong-Ouk, Sul, Jeong-Dug, Park, Channy, Chung, Sang-Young, Moon, Sung-Kyun, Lim, David J, So, Hong-Seob, Park, Raekil
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2011
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203698/
https://ncbi.nlm.nih.gov/pubmed/21321603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2011.27
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