GSK3-mediated instability of tubulin polymers is responsible for the failure of immature CD4+CD8+ thymocytes to polarize their MTOC in response to TCR stimulation

Ítems similars

• Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+ CD8+ thymocytes: increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability, improves TCR assembly, and parallels other indicators of positive selection
  Publicat: (1995)
• T Cell Receptor (TCR)-induced Death of Immature CD4(+)CD8(+) Thymocytes by Two Distinct Mechanisms Differing in Their Requirement for CD28 Costimulation: Implications for Negative Selection in the Thymus
  per: Punt, Jennifer A., et al.
  Publicat: (1997)
• Regulation of T cell receptor (TCR) β gene expression by CD3 complex signaling in immature thymocytes: Implications for TCRβ allelic exclusion
  per: Biro, Judit, et al.
  Publicat: (1999)
• Instability of assembled T-cell receptor complex that is associated with rapid degradation of zeta chains in immature CD4+CD8+ thymocytes.
  per: Kosugi, A, et al.
  Publicat: (1992)
• Induction of IL-15 by TCR/CD3 aggregation depends on IFN-γ and protects against apoptosis of immature thymocytes in vivo
  per: Matthys, P, et al.
  Publicat: (2002)