GSK3-mediated instability of tubulin polymers is responsible for the failure of immature CD4+CD8+ thymocytes to polarize their MTOC in response to TCR stimulation

Although mature T cells divide and differentiate when they receive strong TCR stimulation, most immature CD4+CD8+ thymocytes die. The molecular basis for this marked difference in response is not known. Observations that TCR-stimulated CD4+CD8+ thymocytes fail to polarize their microtubule-organizin...

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Detalhes bibliográficos
Main Authors: Cunningham, Nicole R., Hinchcliff, Emily M., Kutyavin, Vassily I., Beck, Thomas, Reid, Whitney A., Punt, Jenni A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Original Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203681/
https://ncbi.nlm.nih.gov/pubmed/21937454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxr076
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