Diverse substrate recognition and hydrolysis mechanisms of human NUDT5

Human NUDT5 (hNUDT5) hydrolyzes various modified nucleoside diphosphates including 8-oxo-dGDP, 8-oxo-dADP and ADP-ribose (ADPR). However, the structural basis of the broad substrate specificity remains unknown. Here, we report the crystal structures of hNUDT5 complexed with 8-oxo-dGDP and 8-oxo-dADP...

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Detalhes bibliográficos
Main Authors: Arimori, Takao, Tamaoki, Haruhiko, Nakamura, Teruya, Kamiya, Hiroyuki, Ikemizu, Shinji, Takagi, Yasumitsu, Ishibashi, Toru, Harashima, Hideyoshi, Sekiguchi, Mutsuo, Yamagata, Yuriko
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203587/
https://ncbi.nlm.nih.gov/pubmed/21768126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr575
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