ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif

Dysregulated bone morphogenetic protein (BMP) signaling in endothelial cells (ECs) and pulmonary arterial smooth muscle cells (PASMCs) are implicated in human genetic disorders. Here, we generated genome-wide maps of Smad1/5 binding sites in ECs and PASMCs. Smad1/5 preferentially bound to the region...

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Main Authors: Morikawa, Masato, Koinuma, Daizo, Tsutsumi, Shuichi, Vasilaki, Eleftheria, Kanki, Yasuharu, Heldin, Carl-Henrik, Aburatani, Hiroyuki, Miyazono, Kohei
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2011
Teme:
Gene Regulation, Chromatin and Epigenetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203580/
https://ncbi.nlm.nih.gov/pubmed/21764776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr572
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