Mutation in an intervening sequence splice junction in man.
The alpha 2-globin gene of an individual with alpha-thalassemia associated with the absence of alpha 2 mRNA was cloned in bacteriophage. This mutant globin gene was normally active in transcription in vitro. The DNA sequence of the gene, however, revealed a pentanucleotide deletion within the 5' spl...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1981
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC320328/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6946451/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.8.5041 |
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