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Mutation in an intervening sequence splice junction in man.

The alpha 2-globin gene of an individual with alpha-thalassemia associated with the absence of alpha 2 mRNA was cloned in bacteriophage. This mutant globin gene was normally active in transcription in vitro. The DNA sequence of the gene, however, revealed a pentanucleotide deletion within the 5'...

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Detalles Bibliográficos
Main Authors: Orkin, S H, Goff, S C, Hechtman, R L
Formato: Artigo
Idioma:Inglês
Publicado: 1981
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC320328/
https://ncbi.nlm.nih.gov/pubmed/6946451
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