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Mutation in an intervening sequence splice junction in man.
The alpha 2-globin gene of an individual with alpha-thalassemia associated with the absence of alpha 2 mRNA was cloned in bacteriophage. This mutant globin gene was normally active in transcription in vitro. The DNA sequence of the gene, however, revealed a pentanucleotide deletion within the 5'...
Shranjeno v:
| izdano v: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
1981
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC320328/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6946451/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.8.5041 |
| Oznake: |
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