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Kinetics of the viral cycle influence pharmacodynamics of antiretroviral therapy

BACKGROUND: More and more antiretroviral therapies are being developed for treatment of HIV infection. The in-vivo efficacy of these drugs is commonly predicted based on in-vitro measures of antiviral effect. One primary in-vitro measure is the IC50, the amount of drug required for 50% inhibition of...

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Detalhes bibliográficos
Main Authors: Sedaghat, Ahmad R, Wilke, Claus O
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203257/
https://ncbi.nlm.nih.gov/pubmed/21910865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-6150-6-42
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