TAT-mediated delivery of a DNA repair enzyme to skin cells rapidly initiates repair of UV-induced DNA damage

Ultraviolet (UV) light causes DNA damage in skin cells, leading to more than one million cases of non-melanoma skin cancer diagnosed annually in the United States. Although human cells possess a mechanism (Nucleotide Excision Repair, NER) to repair UV-induced DNA damage, mutagenesis still occurs whe...

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Bibliographic Details
Main Authors: Johnson, Jodi L., Lowell, Brian C., Ryabinina, Olga P., Lloyd, R. Stephen, McCullough, Amanda K.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203208/
https://ncbi.nlm.nih.gov/pubmed/20927123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2010.300
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