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Determination of the Biological Activity and Structure Activity Relationships of Drugs Based on the Highly Cytotoxic Duocarmycins and CC-1065

The natural antibiotics CC‑1065 and the duocarmycins are highly cytotoxic compounds which however are not suitable for cancer therapy due to their general toxicity. We have developed glycosidic prodrugs of seco-analogues of these antibiotics for a selective cancer therapy using conjugates of glycohy...

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Detalhes bibliográficos
Main Authors: Tietze, Lutz F., Krewer, Birgit, von Hof, J. Marian, Frauendorf, Holm, Schuberth, Ingrid
Formato: Artigo
Idioma:Inglês
Publicado em: Molecular Diversity Preservation International 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202783/
https://ncbi.nlm.nih.gov/pubmed/22069536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins1020134
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