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Quantification of repolarization reserve to understand inter-patient variability in the response to pro-arrhythmic drugs: a computational analysis

BACKGROUND: "Repolarization reserve" is frequently invoked to explain why potentially pro-arrhythmic drugs cause, across a population, a range of changes to cardiac action potentials (APs). The mechanisms underlying this inter-individual variability, however, are not understood quantitativ...

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Detalhes bibliográficos
Main Authors: Sarkar, Amrita X., Sobie, Eric A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202650/
https://ncbi.nlm.nih.gov/pubmed/21699863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2011.05.023
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