Efficient Generation of Fully Reprogrammed Human iPS Cells via Polycistronic Retroviral Vector and a New Cocktail of Chemical Compounds

Direct reprogramming of human somatic cells into induced pluripotent stem (iPS) cells by defined transcription factors (TFs) provides great potential for regenerative medicine and biomedical research. This procedure has many challenges, including low reprogramming efficiency, many partially reprogra...

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Bibliographic Details
Main Authors: Zhang, Zhonghui, Gao, Yongxing, Gordon, Albert, Wang, Zack Z., Qian, Zhijian, Wu, Wen-Shu
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202534/
https://ncbi.nlm.nih.gov/pubmed/22046312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026592
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