Alcohol Activates TGF-Beta but Inhibits BMP Receptor-Mediated Smad Signaling and Smad4 Binding to Hepcidin Promoter in the Liver

Hepcidin, a key regulator of iron metabolism, is activated by bone morphogenetic proteins (BMPs). Mice pair-fed with regular and ethanol-containing L. De Carli diets were employed to study the effect of alcohol on BMP signaling and hepcidin transcription in the liver. Alcohol induced steatosis and T...

Full description

Saved in:
Bibliographic Details
Main Authors: Gerjevic, Lisa Nicole, Liu, Na, Lu, Sizhao, Harrison-Findik, Duygu Dee
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202137/
https://ncbi.nlm.nih.gov/pubmed/22121494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/459278
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items