Alcohol Activates TGF-Beta but Inhibits BMP Receptor-Mediated Smad Signaling and Smad4 Binding to Hepcidin Promoter in the Liver

Hepcidin, a key regulator of iron metabolism, is activated by bone morphogenetic proteins (BMPs). Mice pair-fed with regular and ethanol-containing L. De Carli diets were employed to study the effect of alcohol on BMP signaling and hepcidin transcription in the liver. Alcohol induced steatosis and T...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Gerjevic, Lisa Nicole, Liu, Na, Lu, Sizhao, Harrison-Findik, Duygu Dee
Materialtyp: Artigo
Språk:Inglês
Publicerad: Hindawi Publishing Corporation 2012
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202137/
https://ncbi.nlm.nih.gov/pubmed/22121494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/459278
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