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The Cellular Prion Protein Prevents Copper-Induced Inhibition of P2X(4) Receptors

Although the physiological function of the cellular prion protein (PrP(C)) remains unknown, several evidences support the notion of its role in copper homeostasis. PrP(C) binds Cu(2+) through a domain composed by four to five repeats of eight amino acids. Previously, we have shown that the perfusion...

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Détails bibliographiques
Auteurs principaux: Lorca, Ramón A., Varela-Nallar, Lorena, Inestrosa, Nibaldo C., Huidobro-Toro, J. Pablo
Format: Artigo
Langue:Inglês
Publié: SAGE-Hindawi Access to Research 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202100/
https://ncbi.nlm.nih.gov/pubmed/22114745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2011/706576
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