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Identification of GABA A receptor modulators in Kadsura longipedunculata and assignment of absolute configurations by quantum-chemical ECD calculations
A petroleum ether extract of Kadsura longipedunculata enhanced the GABA-induced chloride current (I(GABA)) by 122.5 ± 0.3% (n = 2) when tested at 100 μg/ml in Xenopus laevis oocytes expressing GABA A receptors (α(1)β(2)γ(2S) subtype) in two-microelectrode voltage clamp measurements. Thirteen compoun...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3201904/ https://ncbi.nlm.nih.gov/pubmed/21889177 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phytochem.2011.08.014 |
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