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SNVer: a statistical tool for variant calling in analysis of pooled or individual next-generation sequencing data
We develop a statistical tool SNVer for calling common and rare variants in analysis of pooled or individual next-generation sequencing (NGS) data. We formulate variant calling as a hypothesis testing problem and employ a binomial–binomial model to test the significance of observed allele frequency...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3201884/ https://ncbi.nlm.nih.gov/pubmed/21813454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr599 |
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