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Ranking causal variants and associated regions in genome-wide association studies by the support vector machine and random forest

We study the number of causal variants and associated regions identified by top SNPs in rankings given by the popular 1 df chi-squared statistic, support vector machine (SVM) and the random forest (RF) on simulated and real data. If we apply the SVM and RF to the top 2r chi-square-ranked SNPs, where...

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Bibliografiske detaljer
Main Authors: Roshan, Usman, Chikkagoudar, Satish, Wei, Zhi, Wang, Kai, Hakonarson, Hakon
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089490/
https://ncbi.nlm.nih.gov/pubmed/21317188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr064
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