Mechanisms of translational regulation by a human eIF5-mimic protein

The translation factor eIF5 is an important partner of eIF2, directly modulating its function in several critical steps. First, eIF5 binds eIF2/GTP/Met-tRNA(i)(Met) ternary complex (TC), promoting its recruitment to 40S ribosomal subunits. Secondly, its GTPase activating function promotes eIF2 disso...

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Autores principales: Singh, Chingakham Ranjit, Watanabe, Ryosuke, Zhou, Donghui, Jennings, Martin D., Fukao, Akira, Lee, Bumjun, Ikeda, Yuka, Chiorini, John A., Campbell, Susan G., Ashe, Mark P., Fujiwara, Toshinobu, Wek, Ronald C., Pavitt, Graham D., Asano, Katsura
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2011
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201852/
https://ncbi.nlm.nih.gov/pubmed/21745818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr339
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