TOPICAL TENOFOVIR, A MICROBICIDE EFFECTIVE AGAINST HIV, INHIBITS HERPES SIMPLEX VIRUS-2 REPLICATION

The HIV reverse transcriptase inhibitor tenofovir, was recently formulated into a vaginal gel for use as a microbicide. In human trials, a 1% tenofovir gel inhibited HIV sexual transmission by 39% and surprisingly herpes simplex virus-2 (HSV-2) transmission by 51%. We demonstrate that the concentrat...

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Hauptverfasser: Andrei, Graciela, Lisco, Andrea, Vanpouille, Christophe, Introini, Andrea, Balestra, Emanuela, van den Oord, Joost, Cihlar, Tomas, Perno, Carlo-Federico, Snoeck, Robert, Margolis, Leonid, Balzarini, Jan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201796/
https://ncbi.nlm.nih.gov/pubmed/22018238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2011.08.015
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