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Key structural features for substrate binding to organic anion transporter 1 (Oat1; slc22a6) identified by global untargeted metabolomics of Oat1null plasma

Untargeted metabolomics on the plasma and urine from wild-type and organic anion transporter-1 (Oat1/Slc22a6) knockout mice identified a number of physiologically important metabolites, including several not previously linked to Oat1-mediated transport. Several, such as indoxyl sulfate, derive from...

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Detalhes bibliográficos
Main Authors: Wikoff, William R., Nagle, Megha A., Kouznetsova, Valentina L., Tsigelny, Igor F., Nigam, Sanjay K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201759/
https://ncbi.nlm.nih.gov/pubmed/21476605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr200093w
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