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Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids
All organisms, including humans, possess a huge number of uncharacterized enzymes. Here, we describe a general cell-based screen for enzyme substrate discovery by untargeted metabolomics and its application to identify α/β-hydrolase domain-containing 3 (ABHD3) as a lipase that selectively cleaves me...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3201731/ https://ncbi.nlm.nih.gov/pubmed/21926997 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.659 |
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