The glycerophospho-metabolome and its influence on amino acid homeostasis revealed by brain metabolomics of GDE1(-/-) mice

GDE1 is a mammalian glycerophosphodiesterase (GDE) implicated by in vitro studies in the regulation of glycerophopho-inositol (GroPIns) and possibly other glycerophospho (GroP) metabolites. Here, we show using untargeted metabolomics that GroPIns is profoundly (> 20-fold) elevated in brain tissue...

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Detalhes bibliográficos
Main Authors: Kopp, Florian, Komatsu, Toru, Nomura, Daniel K., Trauger, Sunia A., Thomas, Jason R., Siuzdak, Gary, Simon, Gabriel M., Cravatt, Benjamin F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2931592/
https://ncbi.nlm.nih.gov/pubmed/20797612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.06.009
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