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GPCR agonist binding revealed by modeling and crystallography
While structural coverage of the G-protein coupled receptor (GPCR) family steadily improves, high plasticity of these membrane proteins poses additional challenges for crystallographic studies of their complexes with different classes of ligands, especially agonists. Ability to computationally predi...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3200445/ https://ncbi.nlm.nih.gov/pubmed/21903279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2011.08.001 |
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