The Soluble Guanylate Cyclase Stimulator BAY 41-2272 Inhibits Vascular Smooth Muscle Growth through the cAMP-Dependent Protein Kinase and cGMP-Dependent Protein Kinase Pathways

Vascular smooth muscle (VSM) proliferation and migration are key components in vessel remodeling. Cyclic nucleotide signaling is protective and has long-served as a therapeutic target against undesired VSM growth. The present work analyzed the effects of the soluble guanylate cyclase (sGC) stimulato...

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Hlavní autoři: Joshi, Chintamani N., Martin, Danielle N., Fox, Jonathan C., Mendelev, Natalia N., Brown, Trisha A., Tulis, David A.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2011
Témata:
Cardiovascular
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199990/
https://ncbi.nlm.nih.gov/pubmed/21825001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.183400
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