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Screening the MayBridge Rule of 3 Fragment Library for Compounds That Interact with the Trypanosoma brucei myo-Inositol-3-Phosphate Synthase and/or Show Trypanocidal Activity

Inositol-3-phosphate synthase (INO1) has previously been genetically validated as a drug target against Trypanosoma brucei, the causative agent of African sleeping sickness. Chemical intervention of this essential enzyme could lead to new therapeutic agents. Unfortunately, no potent inhibitors of IN...

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Detalhes bibliográficos
Main Authors: Major, Louise L., Smith, Terry K.
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE-Hindawi Access to Research 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199943/
https://ncbi.nlm.nih.gov/pubmed/22091402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2011/389364
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