Chapter 14 Coupled Enzyme Activity and Thermal Shift Screening of the Maybridge Rule of 3 Fragment Library Against Trypanosoma brucei Choline Kinase; A Genetically Validated Drug Target

In this study we interrogate 630 compounds of the Maybridge Rule of 3 Fragment Library for compounds that interact with, and inhibit TbCK. The Maybridge Rule of 3 Fragment Library is a small collection of quantifiable diverse, pharmacophoric rich, chemical entities that comply with the following cri...

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Bibliografische gegevens
Hoofdauteurs: Denton, Helen, Major, Louise L., Smith, Terry K.
Formaat: Livro
Taal:Inglês
Gepubliceerd in: InTechOpen 2013
Onderwerpen:
pharmacology
toxicology
Assay
Enzyme
Molar concentration
Protein
Thermal shift assay
Trypanosoma brucei
thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
Online toegang:https://directory.doabooks.org/handle/20.500.12854/30669
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