Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence

BACKGROUND: There are several studies reporting association of alpha-4 nicotinic acetylcholine receptors (encoded by CHRNA4) with nicotine dependence (ND). A meta-analysis of genomewide linkage studies for ND implicated a single chromosomal region, which includes CHRNA4, as genomewide significant. M...

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Main Authors: Xie, Pingxing, Kranzler, Henry R., Krauthammer, Michael, Cosgrove, Kelly P., Oslin, David, Anton, Raymond F., Farrer, Lindsay A., Picciotto, Marina R., Krystal, John H., Zhao, Hongyu, Gelernter, Joel
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199609/
https://ncbi.nlm.nih.gov/pubmed/21683344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2011.04.017
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