The Large Extracellular Loop of Organic Cation Transporter 1 Influences Substrate Affinity and Is Pivotal for Oligomerization

Polyspecific organic anion transporters (OATs) and organic cation transporters (OCTs) of the SLC22 transporter family play a pivotal role in absorption, distribution, and excretion of drugs. Polymorphisms in these transporters influence therapeutic effects. On the basis of functional characterizatio...

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Detalhes bibliográficos
Main Authors: Keller, Thorsten, Egenberger, Brigitte, Gorboulev, Valentin, Bernhard, Frank, Uzelac, Zeljko, Gorbunov, Dmitry, Wirth, Christophe, Koppatz, Stefan, Dötsch, Volker, Hunte, Carola, Sitte, Harald H., Koepsell, Hermann
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199529/
https://ncbi.nlm.nih.gov/pubmed/21896487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.289330
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