2-Thioxanthines Are Mechanism-based Inactivators of Myeloperoxidase That Block Oxidative Stress during Inflammation

Myeloperoxidase (MPO) is a prime candidate for promoting oxidative stress during inflammation. This abundant enzyme of neutrophils uses hydrogen peroxide to oxidize chloride to highly reactive and toxic chlorine bleach. We have identified 2-thioxanthines as potent mechanism-based inactivators of MPO...

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Main Authors: Tidén, Anna-Karin, Sjögren, Tove, Svensson, Mats, Bernlind, Alexandra, Senthilmohan, Revathy, Auchère, Francoise, Norman, Henrietta, Markgren, Per-Olof, Gustavsson, Susanne, Schmidt, Staffan, Lundquist, Stefan, Forbes, Louisa V., Magon, Nicholas J., Paton, Louise N., Jameson, Guy N. L., Eriksson, Håkan, Kettle, Anthony J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Enzymology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199503/
https://ncbi.nlm.nih.gov/pubmed/21880720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.266981
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