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Structural Basis for Leucine-induced Allosteric Activation of Glutamate Dehydrogenase

Glutamate dehydrogenase (GDH) catalyzes reversible conversion between glutamate and 2-oxoglutarate using NAD(P)(H) as a coenzyme. Although mammalian GDH is regulated by GTP through the antenna domain, little is known about the mechanism of allosteric activation by leucine. An extremely thermophilic...

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Bibliografische gegevens
Hoofdauteurs: Tomita, Takeo, Kuzuyama, Tomohisa, Nishiyama, Makoto
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2011
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199488/
https://ncbi.nlm.nih.gov/pubmed/21900230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.260265
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