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Structural Basis for Leucine-induced Allosteric Activation of Glutamate Dehydrogenase
Glutamate dehydrogenase (GDH) catalyzes reversible conversion between glutamate and 2-oxoglutarate using NAD(P)(H) as a coenzyme. Although mammalian GDH is regulated by GTP through the antenna domain, little is known about the mechanism of allosteric activation by leucine. An extremely thermophilic...
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| Główni autorzy: | , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society for Biochemistry and Molecular Biology
2011
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3199488/ https://ncbi.nlm.nih.gov/pubmed/21900230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.260265 |
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