Polymeric Structure and Host Toll-like Receptor 4 Dictate Immunogenicity of NY-ESO-1 Antigen in Vivo

In search of intrinsic factors that contribute to the distinctively strong immunogenicity of a non-mutated cancer/testis antigen, we found that NY-ESO-1 forms polymeric structures through disulfide bonds. NY-ESO-1 binding to immature dendritic cells was dependent on its polymeric structure and invol...

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מידע ביבליוגרפי
Main Authors: Liu, Yanan, Tian, Xiaoli, Leitner, Wolfgang W., Aldridge, Michael E., Zheng, Junying, Yu, Zhiya, Restifo, Nicholas P., Weiss, Richard, Scheiblhofer, Sandra, Xie, Chong, Sun, Ren, Cheng, Genhong, Zeng, Gang
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2011
נושאים:
Immunology
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199455/
https://ncbi.nlm.nih.gov/pubmed/21900253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.280123
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