An extended dsRBD with a novel zinc-binding motif mediates nuclear retention of fission yeast Dicer

Dicer proteins function in RNA interference (RNAi) pathways by generating small RNAs (sRNAs). Here, we report the solution structure of the C-terminal domain of Schizosaccharomyces pombe Dicer (Dcr1). The structure reveals an unusual double-stranded RNA binding domain (dsRBD) fold embedding a novel...

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Detalhes bibliográficos
Main Authors: Barraud, Pierre, Emmerth, Stephan, Shimada, Yukiko, Hotz, Hans-Rudolf, Allain, Frédéric H-T, Bühler, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199388/
https://ncbi.nlm.nih.gov/pubmed/21847092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.300
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