Preventive or late administration of anti-NGF therapy attenuates tumor-induced nerve sprouting, neuroma formation and cancer pain

Early, preemptive blockade of nerve growth factor (NGF)/Tropomyosin receptor kinase A (TrkA) attenuates tumor-induced nerve sprouting and bone cancer pain. A critical unanswered question is whether late blockade of NGF/TrkA can attenuate cancer pain once NGF-induced nerve sprouting and neuroma forma...

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Bibliographische Detailangaben
Hauptverfasser: Jimenez-Andrade, Juan Miguel, Ghilardi, Joseph R., Castaneda-Corral, Gabriela, Kuskowski, Michael A., Mantyh, Patrick W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199350/
https://ncbi.nlm.nih.gov/pubmed/21907491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2011.07.020
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