AN EVOLVING CELLULAR PATHOLOGY OCCURS IN DORSAL ROOT GANGLIA, PERIPHERAL NERVE AND SPINAL CORD FOLLOWING INTRAVENOUS ADMINISTRATION OF PACLITAXEL IN THE RAT

Paclitaxel (Taxol®) is a frontline antineoplastic agent used to treat a variety of solid tumors including breast, ovarian, or lung cancer. The major dose limiting side effect of paclitaxel is a peripheral sensory neuropathy that can last days to a lifetime. To begin to understand the cellular events...

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Main Authors: Peters, Christopher M., Jimenez-Andrade, Juan Miguel, Kuskowski, Michael A., Ghilardi, Joseph R., Mantyh, Patrick W.
Format: Artigo
Jezik:Inglês
Izdano: 2007
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2042964/
https://ncbi.nlm.nih.gov/pubmed/17698044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2007.06.066
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