Relative contribution of changes in sodium current vs intercellular coupling on reentry initiation in two dimensional preparations of Plakophilin-2-deficient cardiac cells

BACKGROUND: Loss of expression of the desmosomal protein plakophilin-2 (PKP2) leads to decreased gap junction-mediated (GJ) coupling, and alters the amplitude and kinetics of sodium current in cardiac myocytes. Whether these modifications, alone or in combination, are sufficient to act as arrhythmog...

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Detalhes bibliográficos
Main Authors: Deo, Makarand, Sato, Priscila Y., Musa, Hassan, Lin, Xianming, Pandit, Sandeep V., Delmar, Mario, Berenfeld, Omer
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199345/
https://ncbi.nlm.nih.gov/pubmed/21723844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2011.06.029
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