Loss of Plakophilin-2 Expression Leads to Decreased Sodium Current and Slower Conduction Velocity in Cultured Cardiac Myocytes

RATIONALE: Plakophilin-2 (PKP2) is an essential component of the cardiac desmosome. Recent data show it interacts with other molecules of the intercalated disc. Separate studies show preferential localization of the voltage-gated sodium channel (Na(V)1.5) to this region. OBJECTIVE: to establish the...

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Autores principales: Sato, Priscila Y., Musa, Hassan, Coombs, Wanda, Guerrero-Serna, Guadalupe, Patiño, Gustavo A., Taffet, Steven M., Isom, Lori L., Delmar, Mario
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742576/
https://ncbi.nlm.nih.gov/pubmed/19661460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.201418
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