Targeted Decorin Gene Therapy Delivered with Adeno-Associated Virus Effectively Retards Corneal Neovascularization In Vivo

Decorin, small leucine-rich proteoglycan, has been shown to modulate angiogenesis in nonocular tissues. This study tested a hypothesis that tissue-selective targeted decorin gene therapy delivered to the rabbit stroma with adeno-associated virus serotype 5 (AAV5) impedes corneal neovascularization (...

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Bibliografiske detaljer
Main Authors: Mohan, Rajiv R., Tovey, Jonathan C. K., Sharma, Ajay, Schultz, Gregory S., Cowden, John W., Tandon, Ashish
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198476/
https://ncbi.nlm.nih.gov/pubmed/22039486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026432
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