BRAF Mutations in Advanced Cancers: Clinical Characteristics and Outcomes

BACKGROUND: Oncogenic BRAF mutations have been found in diverse malignancies and activate RAF/MEK/ERK signaling, a critical pathway of tumorigenesis. We examined the clinical characteristics and outcomes of patients with mutant (mut) BRAF advanced cancer referred to phase 1 clinic. METHODS: We revie...

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Bibliografiska uppgifter
Huvudupphovsmän: El-Osta, Hazem, Falchook, Gerald, Tsimberidou, Apostolia, Hong, David, Naing, Aung, Kim, Kevin, Wen, Sijin, Janku, Filip, Kurzrock, Razelle
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2011
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198456/
https://ncbi.nlm.nih.gov/pubmed/22039425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0025806
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