Impaired phosphorylation of Na(+)-K(+)-2Cl(−) cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome

Na(+)-K(+)-2Cl(−) cotransporters (NKCCs), including NKCC1 and renal-specific NKCC2, and the Na(+)-Cl(−) cotransporter (NCC) play pivotal roles in the regulation of blood pressure (BP) and renal NaCl reabsorption. Oxidative stress-responsive kinase-1 (OSR1) is a known upstream regulator of N(K)CCs. W...

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Autori principali: Lin, Shih-Hua, Yu, I-Shing, Jiang, Si-Tse, Lin, Shu-Wha, Chu, Pauling, Chen, Ann, Sytwu, Huey-Kang, Sohara, Eisei, Uchida, Shinichi, Sasaki, Sei, Yang, Sung-Sen
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198379/
https://ncbi.nlm.nih.gov/pubmed/21972418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1107452108
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