APPL1 Counteracts Obesity-Induced Vascular Insulin Resistance and Endothelial Dysfunction by Modulating the Endothelial Production of Nitric Oxide and Endothelin-1 in Mice

OBJECTIVE: Insulin stimulates both nitric oxide (NO)-dependent vasodilation and endothelin-1 (ET-1)–dependent vasoconstriction. However, the cellular mechanisms that control the dual vascular effects of insulin remain unclear. This study aimed to investigate the roles of the multidomain adaptor prot...

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Detalhes bibliográficos
Main Authors: Wang, Yi, Cheng, Kenneth K.Y., Lam, Karen S.L., Wu, Donghai, Wang, Yu, Huang, Yu, Vanhoutte, Paul M., Sweeney, Gary, Li, Yiming, Xu, Aimin
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2011
Assuntos:
Complications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198090/
https://ncbi.nlm.nih.gov/pubmed/21926268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0666
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