Aberrant Accumulation of Undifferentiated Myeloid Cells in the Adipose Tissue of CCR2-Deficient Mice Delays Improvements in Insulin Sensitivity

OBJECTIVE: Mice with CCR2 deficiency are protected from insulin resistance but only after long periods of high-fat diet (HFD) feeding, despite the virtual absence of circulating inflammatory monocytes. We performed a time course study in mice with hematopoietic and global CCR2 deficiency to determin...

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Главные авторы: Gutierrez, Dario A., Kennedy, Arion, Orr, Jeb S., Anderson, Emily K., Webb, Corey D., Gerrald, William K., Hasty, Alyssa H.
Формат: Artigo
Язык:Inglês
Опубликовано: American Diabetes Association 2011
Предметы:
Obesity Studies
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198070/
https://ncbi.nlm.nih.gov/pubmed/21926275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0314
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