Increased Phagocyte-Like NADPH Oxidase and ROS Generation in Type 2 Diabetic ZDF Rat and Human Islets: Role of Rac1–JNK1/2 Signaling Pathway in Mitochondrial Dysregulation in the Diabetic Islet

OBJECTIVE: To determine the subunit expression and functional activation of phagocyte-like NADPH oxidase (Nox), reactive oxygen species (ROS) generation and caspase-3 activation in the Zucker diabetic fatty (ZDF) rat and diabetic human islets. RESEARCH DESIGN AND METHODS: Expression of core componen...

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Detalhes bibliográficos
Main Authors: Syed, Ismail, Kyathanahalli, Chandrashekara N., Jayaram, Bhavaani, Govind, Sudha, Rhodes, Christopher J., Kowluru, Renu A., Kowluru, Anjaneyulu
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2011
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198065/
https://ncbi.nlm.nih.gov/pubmed/21911753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0809
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