Isoprenylcysteine carboxyl methyltransferase facilitates glucose-induced Rac1 activation, ROS generation and insulin secretion in INS 832/13 β-cells

Isoprenylcysteine carboxyl methyltransferase (ICMT) catalyzes the post-translational methylation of C-terminal cysteines of isoprenylated proteins, including small G-proteins and the γ-subunits of heterotrimeric G-proteins. It is widely felt that carboxymethylation promotes efficient membrane associ...

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Detalhes bibliográficos
Main Authors: Jayaram, Bhavaani, Syed, Ismail, Singh, Alka, Subasinghe, Wasanthi, Kyathanahalli, Chandrashekara N, Kowluru, Anjaneyulu
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2011
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092562/
https://ncbi.nlm.nih.gov/pubmed/21346419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/isl.3.2.15016
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