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Intracellular disruption of rat heart lysosomes by leucine methyl ester: effects on protein degradation.

Perfusion of rat hearts with Krebs--Henseleit medium containing 10 mM L-leucine methyl ester leads to swelling of lysosomes and loss of lysosomal integrity within 30-60 min. No morphological changes can be detected in the nuclei, mitochondria, sarcoplasmic reticulum, or Golgi complex as a result of...

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Main Authors: Reeves, J P, Decker, R S, Crie, J S, Wildenthal, K
格式: Artigo
語言:Inglês
出版: 1981
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC319803/
https://ncbi.nlm.nih.gov/pubmed/7027260
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