Leptin deficiency suppresses MMTV-Wnt-1 mammary tumor growth in obese mice and abrogates tumor initiating cell survival

Obesity increases both the risk and mortality associated with many types of cancer including that of the breast. In mice, obesity increases both incidence of spontaneous tumors and burden of transplanted tumors. Our findings identify leptin, an adipose secreted cytokine, in promoting increased mamma...

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Detaylı Bibliyografya
Asıl Yazarlar: Zheng, Qiao, Dunlap, Sarah M., Zhu, Jinling, Downs-Kelly, Erinn, Rich, Jeremy N., Hursting, Stephen D., Berger, Nathan A., Reizes, Ofer
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2011
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197719/
https://ncbi.nlm.nih.gov/pubmed/21636700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/ERC-11-0102
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