A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol

Recent genome-wide association (GWA) studies described 95 loci controlling serum lipid levels. These common variants explain ∼25% of the heritability of the phenotypes. To date, no unbiased screen for gene–environment interactions for circulating lipids has been reported. We screened for variants th...

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প্রধান লেখক: Surakka, Ida, Isaacs, Aaron, Karssen, Lennart C., Laurila, Pirkka-Pekka P., Middelberg, Rita P. S., Tikkanen, Emmi, Ried, Janina S., Lamina, Claudia, Mangino, Massimo, Igl, Wilmar, Hottenga, Jouke-Jan, Lagou, Vasiliki, van der Harst, Pim, Mateo Leach, Irene, Esko, Tõnu, Kutalik, Zoltán, Wainwright, Nicholas W., Struchalin, Maksim V., Sarin, Antti-Pekka, Kangas, Antti J., Viikari, Jorma S., Perola, Markus, Rantanen, Taina, Petersen, Ann-Kristin, Soininen, Pasi, Johansson, Åsa, Soranzo, Nicole, Heath, Andrew C., Papamarkou, Theodore, Prokopenko, Inga, Tönjes, Anke, Kronenberg, Florian, Döring, Angela, Rivadeneira, Fernando, Montgomery, Grant W., Whitfield, John B., Kähönen, Mika, Lehtimäki, Terho, Freimer, Nelson B., Willemsen, Gonneke, de Geus, Eco J. C., Palotie, Aarno, Sandhu, Manj S., Waterworth, Dawn M., Metspalu, Andres, Stumvoll, Michael, Uitterlinden, André G., Jula, Antti, Navis, Gerjan, Wijmenga, Cisca, Wolffenbuttel, Bruce H. R., Taskinen, Marja-Riitta, Ala-Korpela, Mika, Kaprio, Jaakko, Kyvik, Kirsten O., Boomsma, Dorret I., Pedersen, Nancy L., Gyllensten, Ulf, Wilson, James F., Rudan, Igor, Campbell, Harry, Pramstaller, Peter P., Spector, Tim D., Witteman, Jacqueline C. M., Eriksson, Johan G., Salomaa, Veikko, Oostra, Ben A., Raitakari, Olli T., Wichmann, H.-Erich, Gieger, Christian, Järvelin, Marjo-Riitta, Martin, Nicholas G., Hofman, Albert, McCarthy, Mark I., Peltonen, Leena, van Duijn, Cornelia M., Aulchenko, Yurii S., Ripatti, Samuli
বিন্যাস: Artigo
ভাষা:Inglês
প্রকাশিত: Public Library of Science 2011
বিষয়গুলি:
Research Article
অনলাইন ব্যবহার করুন:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197672/
https://ncbi.nlm.nih.gov/pubmed/22028671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002333
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