Retroviral Integration Mutagenesis in Mice and Comparative Analysis in Human AML Identify Reduced PTP4A3 Expression as a Prognostic Indicator

Acute myeloid leukemia (AML) results from multiple genetic and epigenetic aberrations, many of which remain unidentified. Frequent loss of large chromosomal regions marks haplo-insufficiency as one of the major mechanisms contributing to leukemogenesis. However, which haplo-insufficient genes (HIGs)...

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Detalhes bibliográficos
Main Authors: Beekman, Renée, Valkhof, Marijke, Erkeland, Stefan J., Taskesen, Erdogan, Rockova, Veronika, Peeters, Justine K., Valk, Peter J. M., Löwenberg, Bob, Touw, Ivo P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197662/
https://ncbi.nlm.nih.gov/pubmed/22028901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026537
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